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Image Search Results
Journal: BMC Cancer
Article Title: Mammary tumors alter the fecal bacteriome and permit enteric bacterial translocation
doi: 10.1186/s12885-022-09274-0
Figure Lengend Snippet: Mammary tumors increase splenic bacterial burden and alter splenic cytokines. Tumor mice exhibit splenomegaly that is attenuated in Resected ( A ). Tumor mice also have increased splenic bacterial burden as detected by FISH ( B ). Tumor mice also have altered splenic cytokine profiles ( C ). Control, Tumor, and Resected mice do not differ in the number of animals with culture-positive spleens (60, 66.7, and 66.7% respectively,chi-square likelihood ratio p = 0.96), but Tumor mice tend to have less Lactobacillus -positive spleens ( D ). * = p < 0.05, ** = p < 0.01, *** = p < 0.0001, NS=Not Significant, ND=Not Detected, by ANOVA and post-hoc LSD
Article Snippet: The concentration of IL-10, IL-1β, IL-6, CXCL1, MCP-1, and TNFα were measured using a
Techniques: Control
Journal: BMC Cancer
Article Title: Mammary tumors alter the fecal bacteriome and permit enteric bacterial translocation
doi: 10.1186/s12885-022-09274-0
Figure Lengend Snippet: Working paradigm - Tumor-induced intestinal barrier disruption is permissive of enteric bacterial translocation. Tumors induce intestinal barrier disruption and decrease relative abundance of Lactobacillus through yet unknown mechanisms. Reduced abundance of Lactobacillus and barrier disruption allow higher enteric bacterial translocation to systemic sights including the spleen, where pro-inflammatory cytokine TNFα is reduced. These changes in intestinal physiology and immune function likely contribute to gastrointestinal and behavioral symptoms experienced by patients with cancer
Article Snippet: The concentration of IL-10, IL-1β, IL-6, CXCL1, MCP-1, and TNFα were measured using a
Techniques: Disruption, Translocation Assay